Scientific program / preliminary program
| 18:00-19:00 | ESBRA BOARD MEETING 1 |
| 09:00 - 10:00 | Registration |
| 10:00 - 10:30 | Opening Ceremony Sebastian Mueller, Ioan Sporea |
| 10:30 - 11:00 | Keynote Lecture: Chair: Sebastian Mueller Alcoholic hepatitis – from diagnosis to treatment Phillipe Mathurin |
| 11:00 - 11:30 | Keynote Lecture: Chair: Shilpa Chokshi Alcohol and microbiome in ALD Gyongyi Szabo |
| 11:30 - 12.00 | Coffee break |
| 12.00 - 13:30 | Session 3 - Postgraduate Course Measuring alcohol consumption Chairs: Marcin Wojnar, Rainer Spanagel |
| 12:00 - 12:20 | Tools to detect unhealthy alcohol consumption Friedrich M. Wurst |
| 12:20 - 12:40 | Measuring alcohol consumption Roberta Agabio |
| 12:40 - 13:00 | Diagnosis of alcohol use disorder and identification of unhealthy alcohol consumption Anne Lingford-Hughes |
| 13:00 - 13:20 | Animals models used to study alcohol use disorder Rainer Spanagel |
| 13:20 - 13:30 | Discussions |
| 13:30 - 14:00 | Lunch presentation: Hepatic encephlopathy management-focus on rifaximin – α Alina Popescu |
| 13:30 - 14:30 | Lunch |
| 14:30 - 16:00 | Session 6 - Postgraduate Course EASL ESBRA joint symposium: Epidemiology of ALD: What are the real numbers? Chairs: Emmanuel Tsochatzis, Sebastian Mueller |
| 14:30 - 14:50 | Policies to reduce the burden of ALD Nick Sheran |
| 14:50 - 15:10 | Epidemiology of alcohol-related liver disease in Europe Peter Jepsen |
| 15:10 - 15:30 | Noninvasive biomarker screening and ALD in the general population Maja Thiele |
| 15:30 - 15:50 | Non-invasive fibrosis assessment Emmanuel Tsochatzis |
| 15:50 - 16:00 | Discussions |
| 16:00 - 16:30 | Break |
| 17:30 - 19:00 | Award Ceremony - Romanian National Opera ESBRA life recognition awards Helmut K. Seitz Award donated by the Manfred Lautenschläger Foundation |
| 19:00 - 21:00 | Welcome drinks at the Romanian National Opera |
| 12.00 - 13:30 | Session 1 Mechanisms and Therapeutics of Acute-on-chronic Liver Failure (ACLF) and YIS1 Liver Chairs: Rajiv Jalan, Christophe Moreno |
| 12:00 - 12:20 | Gasdermin-D in endotoxin lethality and AH Gautam Mehta |
| 12:20 - 12:40 | IL-22 for treatment of ACLF Bin Gao |
| 12:40 - 12:50 | Hepatocyte transcriptional reprogramming in AH Josepmaria Argemi |
| 12:50 - 13:00 | Transcriptional changes in the pathological divergence of acute alcoholic hepatitis and cirrhosis Brandon J. Peiffer |
| 13:00 - 13:15 | YAP and liver regeneration in severe AH Line Carolle Ntandja Wandji |
| 13:15 - 13:30 | Treatment of ACLF using synergistic action of G-CSF and TLR4 inhibitor TAK-242 (G-TAK) Cornelius Engelmann |
| 13:45 - 14:30 | Workshop: SuperSonic Mach Protocols. Arsenal of new innovative tools. Multiparametric Assessement of the liver : -Steatosis -Fibrosis -Viscosity (Inflammation) |
| 13:30 - 14:30 | Lunch |
| 14:30 - 16:00 | Session 4 COVID and Alcohol Use Disorder Chairs: Mohsan Subhani, Joaquin Fernandez Sola |
| 14:30 - 14:48 | Introduction COVID and Acohol Use Disorder Jonathan Chick |
| 14:48 - 15:06 | Impact of COVID-19 confinement on alcohol purchases in Great Britain: controlled interrupted time-series analysis during the first half of 2020 compared with 2015-2018 Peter Anderson |
| 15:06 - 15:24 | Lockdown drinking: how alcohol consumption trends have responded to the pandemic Sadie Boniface |
| 15:24 - 15:42 | Treatment and prevention strategies during lockdown Peter Rice |
| 15:42 - 16:00 | The effect of Covid-19 on alcohol use disorder and role of universal alcohol screening in an inpatient setting: a retrospective cohort control study Mohsan Subhani |
| 16:00 - 16:10 | Discussions |
| 12.00-13:30 | Session 2 New mechanisms involved in alcohol use disorder and new therapeutics : insights from the preclinical side Chairs: Mickael Naassila, Sebastien Carnicella |
| 12:00 - 12:20 | Role of GPR88 in alcohol addiction and as a new therapeutic target Sami Ben Hamida |
| 12:20 - 12:40 | Transcranial direct current stimulations (tDCS) reduce motivation to drink ethanol and reacquisition of ethanol self-administration in mice Vincent Van Waes |
| 12:40 - 13:00 | Behavioral and brain Effects of psilocybin in a relevant animal model of binge drinking Jérôme Jeanblanc |
| 13:00 - 13:20 | Role of nigrostriatal pathway in motivated behaviors and alcohol use disorder Raphaël Goutaudier |
| 13:20 - 13:30 | Discussions |
| 13:30 - 14:30 | Lunch |
| 14:30 - 16:00 | Session 5 New insights into neuroinflammatory processes induced by ethanol exposure during early or late brain developmental periods Chairs: Oliver Pierrefiche, Maria Pascual |
| 14:30 - 14:50 | Cannabinoids modulate cognitive deficits and neuroinflammation induced by early alcohol exposure Olga Valverde |
| 14:50 - 15:10 | Role of exosomes as biomarkers of the neuroinflammation induced by adolescent binge drinking María Pascual |
| 15:10 - 15:30 | Binge drinking, inflammation and GluN2B subunits: a ménage à trois to explain cognitive deficits and hippocampus plasticity dysfunctions during adolescence in rats Oliver Pierrefiche |
| 15:30 - 15:50 | PET imaging for preclinical investigation of ethanol-induced neuroinflammation in adolescent animals Wadad Saba |
| 15:50 - 16:00 | Discussions |
| 09:00 - 09:30 | Keynote Lecture: Chair: Giovanni Addolorato Transcranial Magnetic Stimulation in addiction therapies Marco Diana |
| 09:30 - 09:40 | Break |
| 09:40 - 11:10 | Session 9 - Postgraduate Course Acute-on-chronic Liver Failure (ACLF) in Alcoholic Hepatitis Patients Chairs: Rajiv Jalan, Sebastian Mueller |
| 09:40 - 10:00 | Overview of ACLF Rajiv Jalan |
| 10:00 - 10:20 | ACLF in Alcoholic Hepatitis Christophe Moreno |
| 10:20 - 10:40 | Translational omic analysis of ACLF in Alcoholic Hepatitis Ramon Bataller |
| 10:40 - 11:00 | Liver transplantation rescues Alcoholic Hepatitis patients with ACLF Alexandre Louvet |
| 11:00 - 11:10 | Discussions |
| 11:10 - 11:30 | Coffee break |
| 11:30 - 13:00 | Session 12 - Postgraduate Course Alcohol effects on brain and treatments Chairs: Giovanni Addolorato, Mickael Naassila |
| 11:30 - 11:50 | Brain alterations and cognitive deficits induced by alcohol use disorder Mickael Naassila |
| 11:50 - 12:10 | Medical treatment of alcohol use disorder: A multidisciplinary approach Julia Sinclair |
| 12:10 - 12:30 | Comorbidity with substance use disorders and/or psychiatric disorders Marcin Wojnar |
| 12:30 - 12:50 | Emergency Room: Acute alcohol intoxication and other alcohol-related acute problems (except AWS) Giovanni Addolorato |
| 12:50 - 13:00 | Discussions |
| 13:00 - 13:20 | Lunch presentation: Probiotics and diarrhea associated with antibiotic use Hepatoprotectors - a universal approach in chronic liver disease Alina Popescu |
| 13:00 - 14:00 | Lunch and Poster Session |
| 14:00 - 14:30 | Keynote Lecture: Chair: Sophie Leclercq Novel medications and addiction Lorenzo Leggio |
| 14:30 - 14:40 | Break |
| 14:40 - 16:10 | Session 15 - Postgraduate Course Alcohol withdrawal and primary care Chairs: Marcin Wojnar, Nicola Kalk |
| 14:40 - 15:00 | Alcohol withdrawal syndrome Nicola Kalk |
| 15:00 - 15:20 | Treatments for Adolescent Alcohol Use Lindsay Squeglia |
| 15:20 - 15:40 | Potential New Medications for the treatment of alcohol use disorder and experimental medications Lorenzo Leggio |
| 15:40 - 16:00 | Fibrosis screening of ALD based on elastography Sebastian Mueller |
| 16:00 - 16:10 | Discussions |
| 16:10 - 16:30 | Coffee break |
| 16:30 - 18:00 | Session 18 - Postgraduate Course Intensive care- Acute alcoholism management Chairs: Dorel Sandesc, Ioan Sporea |
| 16:30 - 16:48 | Acute liver failure due to alcohol intoxication- therapeutic options Carmen Fierbinteanu |
| 16:48 - 17:06 | Severe acute ethanolic intoxication- management of critical ill patient Ovidiu Bedreag |
| 17:06 - 17:24 | Coagulation disorders in patients with alcoholic liver cirrhosis Liana Gheorghe |
| 17:24 - 17:42 | Hepato- renal syndrome in patients with acute alcoholic intoxication Camelia Cojocariu |
| 17:42 - 18:00 | Particularities of intensive care in patients with alcohol use disorder Dorel Sandesc |
| 18:00 - 19:00 | General assembly |
| 20:00 | Get together party - Curtea berarilor - Oktoberfest |
| 20:00 | Poster Awards |
| 09:40 - 11:10 | Session 7 |
| 11:10 - 11:30 | Coffee break |
| 11:30 - 13:00 | Session 10 The role of inter-organ communication in alcohol induced tissue injury Chair: Gautam Mehta, Gyongyi Szabo |
| 11:30 - 11:48 | Elevated intracellular S-adenosylhomocysteine: A recurring finding in ALD pathogenesis Kusum K. Kharbanda |
| 11:48 - 12:06 | Alcohol-induced gut microbial dysbiosis plays a major role in driving the pathogenic changes in the gut-liver-brain-axis Shirish Barve |
| 12:06 - 12:24 | Alcohol-induced tissue injury in skeletal muscle and adipose tissue; targets or relays for interorgan axis Patricia E. Molina |
| 12:24 - 12:48 | Alcohol potentiates HIV-induced hepatotoxicity via induction of lysosomal damage in hepatocytes Natalia A. Osna |
| 12:48 - 13:00 | Impact of alcohol and aldehyde on innate lung defense: Liver-lung axis Todd A. Wyatt |
| 13:45 - 14:30 | Workshop: Personalized Ultrasound Solutions. Because every patient’s care should be as unique as their fingerprint |
| 13:00 - 14:00 | Lunch and Poster Session |
| 14:30 - 14:40 | Break |
| 14:40-16:10 | Session 13 Alcohol-Related liver disease (ALD) – a global epidemic Chair: Shilpa Chokshi, Elena Palma |
| 14:40 - 15:00 | Pathogenesis and diagnosis of ArLD Matthew Cramp |
| 15:00 - 15:20 | Genetic profiling as a tool to advance therapeutic discovery in ArLD Marsha Morgan |
| 15:20 - 15:40 | Mitochondrial therapy for ArLD - fact or fiction? Jose C Fernandez-Checa |
| 15:40 - 16:00 | Big data in ALD: how are multi-omic studies advancing the development of therapeutics for ALD Ramon Bataller |
| 16:00 - 16:10 | Discussions |
| 16:10 - 16:30 | Coffee break |
| 16:30 - 18:00 | Session 16 ALD, NAFLD and bowel disease Chair: Manuela Neuman, Massimo Pinzani, Stephen Malnick |
| 16:30 - 16:40 | Inflammatory bowel disease and alcohol-induced injury Ioana Duca Grigorescu |
| 16:40 - 17:00 | Non-alcoholic steatohepatitis and the microbiome Steve Malnick |
| 17:00 - 17:10 | Dysfunction of Intestinal Antimicrobial Peptides in the Pathogenesis of Alcoholic Hepatitis Wei Zhong |
| 17:10 - 17:20 | H2O2-mediated autophagy during ethanol metabolism Cheng Chen |
| 17:20 - 17:40 | Apoptosome and Inflammasome: Non-invasive biomarkers in heavy drinkers undergoing alcohol detoxification Manuela G. Neuman |
| 17:40 - 17:50 | Chaperone-Mediated Autophagy Substrate Stabilization Potentiates EtOH-Induced Lipogenesis in Liver Cells Paul G. Thomes |
| 17:50 - 18:00 | Discussions |
| 09:40 - 11:10 | Session 8 Translational Neuroimaging in Alcoholism I: Novel approaches to neuro-immune and functional networks Chairs: Wolfgang H. Sommer, Maria Ercsey-Ravasz |
| 09:40 - 10:00 | Alcohol, Microbiota and Brain function Sophie Leclercq |
| 10:00 - 10:20 | Advanced DTI to identify glia responses in the alcoholic brain Silvia De Santis |
| 10:20 - 10:40 | High-density neurometabolic mapping and network analysis in alcohol dependent rats Cornelius C. W. Willacey |
| 10:40 - 11:00 | Advanced Network analysis of cFos responses reveals distinct brain states for alcohol and sweet memory recall Maria Ercsey-Ravasz |
| 11:00 - 11:10 | Discussions |
| 11:10 - 11:30 | Coffee break |
| 11:30 - 13:00 | Session 11 YIS 2 Addiction studies/Nordmann Award Chairs: Raul Muresan, Philippe de Timary |
| 11:30 - 11:50 | Searching for treatment-sensitive neural biomarkers of addiction: is there light at the end of the MRI-tunnel? Patrick Bach (Nordmann Award Winner) |
| 11:50 - 12:00 | Engagement of brain stress-reward systems in alcohol-dependent mice and rats Elizabeth M Avegno |
| 12:00 - 12:10 | LRRK2, a parkinson's-associated protein, regulates striatal D1 receptor function and compulsive-like alcohol drinking in mice Daniel da Silva |
| 12:10 - 12:20 | Memory and synaptic plasticity impairment after the very first binge drinking episodes in adolescent rats: Is there a link between inflammation and glutamate? Chloé Deschamps |
| 12:20 - 12:30 | Discovery and characterization of ADE and non-ADE rats under long-term alcohol exposure protocol. Biochemical differences in rat brain during alcohol abstinence. Sandra Fernández-Rodríguez |
| 12:30 - 12:40 | Identification and validation of expert patient intervention areas in addictology with patients hospitalized for addiction disorders Chanaëlle Obadia |
| 12:40 - 12:50 | A Dominance Analysis Approach Applied to Psychological Factors Associated with Binge Drinking among University Students Maxime Mauduy |
| 12:50 - 13:00 | Discussions |
| 13:00 - 14:00 | Lunch and Poster Session |
| 14:30 - 14:40 | Break |
| 14:40 - 16:10 | Session 14 Diagnosis and Interventions in FASD: From Genes to eHealth Chairs: Rainer Spanagel, Mike Suttie |
| 14:40 - 15:00 | Introductory comments on FASD and the Collaborative Initiative on FASD Edward Riley |
| 15:00 - 15:20 | Exposure to ethanol leads to midfacial hypoplasia in VANGL2 mutants via indirect interactions with the SHH pathway Johann Eberhart |
| 15:20 - 15:40 | The role of sex and genetic variation in a mouse model of FAS Scott Parnell |
| 15:40 - 16:00 | Utilizing 3D facial Analysis to Estimate the Prevalence of Minor Facial Anomalies in FASD Mike Suttie |
| 16:00 - 16:10 | Development and Evaluation of Digital and Mobile Health Interventions (eHealth) for FASD Christie Petrenko |
| 16:10-16:30 | Coffee break |
| 16:30 - 18:00 | Session 17 Translational Neuroimaging in Alcoholism II: Mapping global network interactions Chairs: Wolfgang H. Sommer, Raul Muresan |
| 16:30 - 16:50 | Structural mapping and higher brain function Phillippe de Timary |
| 16:50 - 17:10 | Altered diffusivity in the alcoholic brain - what are the functional consequences Santiago Canals |
| 17:10 - 17:30 | Probing functional brain networks in alcoholism by using advanced signal processing techniques and machine learning Raul Muresan |
| 17:30 - 17:50 | Using machine learning, structural differences in adolescent brains can predict alcohol misuse in the future Roshan Rane |
| 17:50 - 18:00 | Discussions |
| 09:00 - 09:30 | Keynote Lecture: Chair: Ioan Sporea Alcoholic cirrhosis and reversibility Massimo Pinzani |
| 09:30 - 09:40 | Break |
| 09:40 - 11:10 | Session 21 - Postgraduate Course Epidemiology, cancer and neurology in drinkers Chairs: Vasilis Vasiliou, Jürgen Rehm, Manuela Neuman |
| 09:40 - 10:00 | Epidemiology of alcohol and opioids Jürgen Rehm |
| 10:00 - 10:20 | Mechanisms of alcohol-induced cancer Vasilis Vasiliou |
| 10:20 - 10:40 | Alcohol-induced rare malignancy Manuela G. Neuman |
| 10:40 - 11:00 | Wernicke-Korsakoff syndrome Alain Dervaux |
| 11:00 - 11:10 | Discussions |
| 11:10 - 11:40 | Coffee break |
| 11:40 - 12:10 | Keynote Lecture: Chair: Marcin Wojnar Losing and regaining control over alcohol intake Rainer Spanagel |
| 12:20 - 13:20 | Session 24 - Postgraduate Course Legal aspects and management of acute disease Chairs: Roxana Sirli, Camelia Cojocaru |
| 12:20 - 12:35 | Legal aspects of alcoholic intake Alexandra Enache |
| 12:35 - 12:50 | How to manage agressive withdrawal Virgil Enatescu |
| 12:50 - 13:05 | Microbiota and alcoholic liver Alina Popescu |
| 13:05 - 13:20 | AddictHelp: the Cluj experience in interdisciplinary approach of AUD Horia Stefanescu |
| 13:20 - 13:40 | Lunch presentation: Understanding microbiota - autoimmunity, probiotic bacteria and infection Roxana Sirli |
| 13:20 - 14:20 | Lunch |
| 14:20 - 15:50 | Session 27 - Postgraduate Course Alcoholism and the heart liver axis Chairs: Ioan Sporea, Adina Ionac |
| 14:20 - 14:38 | Ethanol and heart failure Adina Ionac |
| 14:38 - 14:56 | French Paradox – truth or challenge Gaita Dan |
| 14:56 - 15:14 | Elastography for screening in ALD Ioan Sporea |
| 15:14 - 15:32 | Alcoholic cardiomyopathy: Pathogenic aspects Joaquim FernÁndez Sola |
| 15:32 - 15:50 | Revisiting the role of HVPG and transjugular liver biopsy in alcoholic hepatitis Bogdan Procopet |
| 15:50-16:00 | Closing Remarks |
| 16:30-18:00 | ESBRA Board meeting 2, New Board |
| 09:40 - 11:10 | Session 19 Alcohol and metabolic syndrome Chairs: Alexandre Louvet, Christophe Moreno |
| 09:40 - 10:00 | Alcohol and metabolic syndrome: clinical aspects Philippe Mathurin |
| 10:00 - 10:20 | Alcohol, metabolic syndrome and the liver: epidemiology Helena Cortez-Pinto |
| 10:20 - 10:40 | Histological lesions can predict response to corticosteroids in patients with severe alcohol-reated steatohepatitis (ASH) Karoline Lackner |
| 10:40 - 11:00 | Screening for NAFLD and ALD in patients with type 2 diabetes and in general population Hannes Hagström |
| 11:00 - 11:10 | Discussions |
| 11:10 - 11:40 | Coffee break |
| 12:20 - 13:20 | Session 22 YIS 4 Liver disease Chairs: Shilpa Chokshi, Karoline Lackner |
| 12:20 - 12:30 | Spleen stiffness to liver stiffness ratio in ALD Omar Elshaarawy |
| 12:30 - 12:40 | Alcohol use disorder and alcohol related liver disease: time for screening? Camelia Foncea |
| 12:40 - 12:50 | Elevated S-adenosylhomocysteine-induced dipose dysfunction promotes alcohol-associated liver steatosis Madan Kumar Arumugam |
| 12:50 - 13:00 | Distinct Mechanisms of Liver Cancers Between Alcoholic and Nonalcohlic Fatty Liver Diseases in Diabetic Murine Models Liya Pi |
| 13:00 - 13:10 | Role of Gut Hormones, Ghrelin and Liver-Expressed Antimicrobial Peptide-2 Dysregulation in Alcohol-Associated Liver Disease Pathogenesis Karuna Rasineni |
| 13:10 - 13:20 | Discussions |
| 13:40 - 14:20 | Workshop |
| 13:20 - 14:20 | Lunch |
| 14:20 - 15:50 | Session 25 Modifiers of alcoholic liver disease Chairs: Steven Dooley, Ina Bergheim |
| 14:20 - 14:40 | Intestinal bacteria and bacterial endotoxin in the development and therapy of alcohol-related liver disease Ina Bergheim |
| 14:40 - 15:00 | Alcohol-related liver disease, hemolysis and iron signaling Shijin Wang |
| 15:00 - 15:20 | Role of environmental toxins and nanoplastics in the pathogenesis of (N)AFLD Felix Englert |
| 15:20 - 15:40 | Influence of hepatic preinjury on development of alcohol-related and other chronic liver disease Steven Dooley |
| 15:40 - 15:50 | Discussions |
| 09:40 - 11:10 | Session 20 YIS3 addiction studies Chair: Mickael Naassila, Oliver Pierrefiche |
| 09:40 - 09:50 | More than just an alcoholic person: Preventing stigma and dehumanization with multiple categorization Pauline Rasset |
| 09:50 - 10:00 | Epigenetic mechanisms underlying alcohol use and anxiety disorders Estelle Barbier |
| 10:00 - 10:10 | Early recovery of neuropsychological impairments during detoxification in patients with alcohol use disorder Bernard Angerville |
| 10:10 - 10:20 | Adverse childhood experiences (ACES) in young children with fetal alcohol spectrum disorder (FASD) and effect on behavior problems Carson Kautz-Turnbull |
| 10:20 - 10:30 | Pilot study CANNAVAP: efficiency of cannbidiol inhaled with a vaping device in cannabis reduction or withdrawal Gregoire Cleirec |
| 10:30 - 10:40 | Benefits of abstinence of chronic alcohol exposure-induced aggressiveness in cellular models of hepatocellular carcinoma Constance Marié |
| 10:40 - 10:50 | Deep transcranial magnetic stimulation as a treatment for alcohol use disorderIrene Perini |
| 10:50 - 11:00 | Discussions |
| 11:10 - 11:40 | Coffee break |
| 12:20 - 13:20 | Session 23 From 3-R to 6-R: Improved ethics for the use of animals towards narrowing the translational gap in alcohol use disorder Chair: Marcus Meinhardt, Björn Gerlach |
| 12:20 - 12:35 | Refining animal models in the field of alcohol use disorder Marcus Meinhardt |
| 12:35 - 12:50 | The PREPARE guidelines: An overarching guidance on how to plan animal experiments Adrian Smith |
| 12:50 - 13:05 | EQIPD - A systematic approach to enhance research data quality Björn Gerlach |
| 13:05 - 13:20 | Reporting guidelines for non-clinical data Kaitlyn Hair |
| 13:20 - 14:20 | Lunch |
| 14:20 - 15:50 | Session 26 Alcohol and Older Adults: Insights from Behavioral and Brain Studies Chair: Mickael Naassila, Wolfgang Sommer |
| 14:20 - 14:40 | Epidemiology of Harmful Drinking Among Older Adults: Life Course Origins and Public Health Implications Katherine M. Keyes |
| 14:40 - 15:00 | Age-related Vulnerability at Socially-Relevant Doses Sara Jo Nixon |
| 15:00 - 15:20 | Neuroinflammation al the intersection between alcohol and aging Terence Deak |
| 15:20 - 15:40 | Increased sensitivity to ethanol in aged animals: potential neurobiological mechanisms Douglas B Matthews |
| 15:40 - 15:50 | Discussions |
1.10.2021
Early bird
registration
Early bird
registration
05.09.2021
Deadline abstract
submission
Deadline abstract
submission
15.09.2021
Abstract acceptance
notification
Abstract acceptance
notification
3 Victor Babes street, ap. 3
Cluj-Napoca, Romania
+40 364 146 681
esbra@medevents.ro
