Scientific program 2021-09-15T19:15:38+00:00

Scientific program / preliminary program

09:00 - 10:00Registration
10:00 - 10:30Opening Ceremony
Sebastian Mueller, Ioan Sporea
10:30 - 11:00Keynote Lecture:
Chair: Sebastian Mueller
Alcoholic hepatitis – from diagnosis to treatment
Phillipe Mathurin
11:00 - 11:30Keynote Lecture:
Chair: Shilpa Chokshi
Alcohol and microbiome in ALD
Gyongyi Szabo
11:30 - 12.00Coffee break
12.00 - 13:30Session 3 - Postgraduate Course
Measuring alcohol consumption
Chairs: Marcin Wojnar, Rainer Spanagel
12:00 - 12:20Tools to detect unhealthy alcohol consumption
Friedrich M. Wurst
12:20 - 12:40Measuring alcohol consumption
Roberta Agabio
12:40 - 13:00Diagnosis of alcohol use disorder and identification of unhealthy alcohol consumption
Anne Lingford-Hughes
13:00 - 13:20Animals models used to study alcohol use disorder
Rainer Spanagel
13:20 - 13:30Discussions
13:30 - 14:00Lunch presentation: Hepatic encephlopathy management-focus on rifaximin – α
Alina Popescu
13:30 - 14:30Lunch
14:30 - 16:00Session 6 - Postgraduate Course
EASL ESBRA joint symposium: Epidemiology of ALD: What are the real numbers?
Chairs: Emmanuel Tsochatzis, Sebastian Mueller
14:30 - 14:50Policies to reduce the burden of ALD
Nick Sheran
14:50 - 15:10Epidemiology of alcohol-related liver disease in Europe
Peter Jepsen
15:10 - 15:30Noninvasive biomarker screening and ALD in the general population
Maja Thiele
15:30 - 15:50Non-invasive fibrosis assessment
Emmanuel Tsochatzis
15:50 - 16:00Discussions
16:00 - 16:30Break
17:30 - 19:00Award Ceremony - Romanian National Opera
ESBRA life recognition awards
Helmut K. Seitz Award donated by the Manfred Lautenschläger Foundation
19:00 - 21:00 Welcome drinks at the Romanian National Opera
12.00 - 13:30Session 1
Mechanisms and Therapeutics of Acute-on-chronic Liver Failure (ACLF) and YIS1 Liver
Chairs: Rajiv Jalan, Christophe Moreno
12:00 - 12:20Gasdermin-D in endotoxin lethality and AH
Gautam Mehta
12:20 - 12:40IL-22 for treatment of ACLF
Bin Gao
12:40 - 12:50Hepatocyte transcriptional reprogramming in AH
Josepmaria Argemi
12:50 - 13:00Transcriptional changes in the pathological divergence of acute alcoholic hepatitis and cirrhosis
Brandon J. Peiffer
13:00 - 13:15YAP and liver regeneration in severe AH
Line Carolle Ntandja Wandji
13:15 - 13:30Treatment of ACLF using synergistic action of G-CSF and TLR4 inhibitor TAK-242 (G-TAK)
Cornelius Engelmann
13:45 - 14:30Workshop:  
SuperSonic Mach Protocols.
Arsenal of new innovative tools.
Multiparametric Assessement of the liver :
-Viscosity (Inflammation) 
13:30 - 14:30Lunch
14:30 - 16:00Session 4
COVID and Alcohol Use Disorder
Chairs: Mohsan Subhani, Joaquin Fernandez Sola
14:30 - 14:48Introduction COVID and Acohol Use Disorder
Jonathan Chick
14:48 - 15:06Impact of COVID-19 confinement on alcohol purchases in Great Britain: controlled interrupted time-series analysis during the first half of 2020 compared with 2015-2018
Peter Anderson
15:06 - 15:24Lockdown drinking: how alcohol consumption trends have responded to the pandemic
Sadie Boniface
15:24 - 15:42Treatment and prevention strategies during lockdown
Peter Rice
15:42 - 16:00The effect of Covid-19 on alcohol use disorder and role of universal alcohol screening in an inpatient setting: a retrospective cohort control study
Mohsan Subhani
16:00 - 16:10 Discussions
12.00-13:30Session 2
New mechanisms involved in alcohol use disorder and new therapeutics : insights from the preclinical side 
Chairs: Mickael Naassila, Sebastien Carnicella
12:00 - 12:20Role of GPR88 in alcohol addiction and as a new therapeutic target
Sami Ben Hamida
12:20 - 12:40Transcranial direct current stimulations (tDCS) reduce motivation to drink ethanol and reacquisition of ethanol self-administration in mice
Vincent Van Waes
12:40 - 13:00Behavioral and brain Effects of psilocybin in a relevant animal model of binge drinking
Jérôme Jeanblanc
13:00 - 13:20Role of nigrostriatal pathway in motivated behaviors and alcohol use disorder
Raphaël Goutaudier
13:20 - 13:30Discussions
13:30 - 14:30Lunch
14:30 - 16:00Session 5
New insights into neuroinflammatory processes induced by ethanol exposure during early or late brain developmental periods
Chairs: Oliver Pierrefiche, Maria Pascual
14:30 - 14:50Cannabinoids modulate cognitive deficits and neuroinflammation induced by early alcohol exposure
Olga Valverde
14:50 - 15:10Role of exosomes as biomarkers of the neuroinflammation induced by adolescent binge drinking
María Pascual
15:10 - 15:30Binge drinking, inflammation and GluN2B subunits: a ménage à trois to explain cognitive deficits and hippocampus plasticity dysfunctions during adolescence in rats
Oliver Pierrefiche
15:30 - 15:50PET imaging for preclinical investigation of ethanol-induced neuroinflammation in adolescent animals
Wadad Saba
15:50 - 16:00Discussions
09:00 - 09:30Keynote Lecture:
Chair: Giovanni Addolorato
Transcranial Magnetic Stimulation in addiction therapies
Marco Diana
09:30 - 09:40Break
09:40 - 11:10Session 9 - Postgraduate Course
Acute-on-chronic Liver Failure (ACLF) in Alcoholic Hepatitis Patients
Chairs: Rajiv Jalan, Sebastian Mueller
09:40 - 10:00Overview of ACLF
Rajiv Jalan
10:00 - 10:20ACLF in Alcoholic Hepatitis
Christophe Moreno
10:20 - 10:40Translational omic analysis of ACLF in Alcoholic Hepatitis
Ramon Bataller
10:40 - 11:00Liver transplantation rescues Alcoholic Hepatitis patients with ACLF
Alexandre Louvet
11:00 - 11:10Discussions
11:10 - 11:30Coffee break
11:30 - 13:00Session 12 - Postgraduate Course
Alcohol effects on brain and treatments
Chairs: Giovanni Addolorato, Mickael Naassila
11:30 - 11:50Brain alterations and cognitive deficits induced by alcohol use disorder
Mickael Naassila
11:50 - 12:10Medical treatment of alcohol use disorder: A multidisciplinary approach
Julia Sinclair
12:10 - 12:30Comorbidity with substance use disorders and/or psychiatric disorders
Marcin Wojnar
12:30 - 12:50Emergency Room: Acute alcohol intoxication and other alcohol-related acute problems (except AWS)
Giovanni Addolorato
12:50 - 13:00Discussions
13:00 - 13:20Lunch presentation:
Probiotics and diarrhea associated with antibiotic use
Hepatoprotectors - a universal approach in chronic liver disease
Alina Popescu
13:00 - 14:00Lunch and Poster Session
14:00 - 14:30Keynote Lecture:
Chair: Sophie Leclercq
Novel medications and addiction
Lorenzo Leggio
14:30 - 14:40Break
14:40 - 16:10Session 15 - Postgraduate Course
Alcohol withdrawal and primary care
Chairs: Marcin Wojnar, Nicola Kalk
14:40 - 15:00Alcohol withdrawal syndrome
Nicola Kalk
15:00 - 15:20Treatments for Adolescent Alcohol Use
Lindsay Squeglia
15:20 - 15:40Potential New Medications for the treatment of alcohol use disorder and experimental medications
Lorenzo Leggio
15:40 - 16:00Fibrosis screening of ALD based on elastography
Sebastian Mueller
16:00 - 16:10Discussions
16:10 - 16:30Coffee break
16:30 - 18:00Session 18 - Postgraduate Course
Intensive care- Acute alcoholism management
Chairs: Dorel Sandesc, Ioan Sporea
16:30 - 16:48Acute liver failure due to alcohol intoxication- therapeutic options
Carmen Fierbinteanu
16:48 - 17:06Severe acute ethanolic intoxication- management of critical ill patient
Ovidiu Bedreag
17:06 - 17:24Coagulation disorders in patients with alcoholic liver cirrhosis
Liana Gheorghe
17:24 - 17:42Hepato- renal syndrome in patients with acute alcoholic intoxication
Camelia Cojocariu
17:42 - 18:00Particularities of intensive care in patients with alcohol use disorder
Dorel Sandesc
18:00 - 19:00General assembly
20:00Get together party - Curtea berarilor - Oktoberfest
20:00Poster Awards
09:40 - 11:10Session 7
11:10 - 11:30Coffee break
11:30 - 13:00Session 10
The role of inter-organ communication in alcohol induced tissue injury
Chair: Gautam Mehta, Gyongyi Szabo
11:30 - 11:48Elevated intracellular S-adenosylhomocysteine: A recurring finding in ALD pathogenesis
Kusum K. Kharbanda
11:48 - 12:06Alcohol-induced gut microbial dysbiosis plays a major role in driving the pathogenic changes in the gut-liver-brain-axis
Shirish Barve
12:06 - 12:24Alcohol-induced tissue injury in skeletal muscle and adipose tissue; targets or relays for interorgan axis
Patricia E. Molina
12:24 - 12:48Alcohol potentiates HIV-induced hepatotoxicity via induction of lysosomal damage in hepatocytes
Natalia A. Osna
12:48 - 13:00Impact of alcohol and aldehyde on innate lung defense: Liver-lung axis
Todd A. Wyatt
13:45 - 14:30Workshop:
Personalized Ultrasound Solutions. Because every patient’s care should be as unique as their fingerprint
13:00 - 14:00Lunch and Poster Session
14:30 - 14:40Break
14:40-16:10Session 13
Alcohol-Related liver disease (ALD) – a global epidemic
Chair: Shilpa Chokshi, Elena Palma
14:40 - 15:00Pathogenesis and diagnosis of ArLD
Matthew Cramp
15:00 - 15:20Genetic profiling as a tool to advance therapeutic discovery in ArLD
Marsha Morgan
15:20 - 15:40Mitochondrial therapy for ArLD - fact or fiction?
Jose C Fernandez-Checa
15:40 - 16:00Big data in ALD: how are multi-omic studies advancing the development of therapeutics for ALD
Ramon Bataller
16:00 - 16:10Discussions
16:10 - 16:30Coffee break
16:30 - 18:00Session 16
ALD, NAFLD and bowel disease
Chair: Manuela Neuman, Massimo Pinzani, Stephen Malnick
16:30 - 16:40Inflammatory bowel disease and alcohol-induced injury
Ioana Duca Grigorescu
16:40 - 17:00Non-alcoholic steatohepatitis and the microbiome
Steve Malnick
17:00 - 17:10Dysfunction of Intestinal Antimicrobial Peptides in the Pathogenesis of Alcoholic Hepatitis
Wei Zhong
17:10 - 17:20H2O2-mediated autophagy during ethanol metabolism
Cheng Chen
17:20 - 17:40Apoptosome and Inflammasome: Non-invasive biomarkers in heavy drinkers undergoing alcohol detoxification
Manuela G. Neuman
17:40 - 17:50Chaperone-Mediated Autophagy Substrate Stabilization Potentiates EtOH-Induced Lipogenesis in Liver Cells
Paul G. Thomes
17:50 - 18:00Discussions
09:40 - 11:10Session 8
Translational Neuroimaging in Alcoholism I: Novel approaches to neuro-immune and functional networks
Chairs: Wolfgang H. Sommer, Maria Ercsey-Ravasz
09:40 - 10:00Alcohol, Microbiota and Brain function
Sophie Leclercq
10:00 - 10:20Advanced DTI to identify glia responses in the alcoholic brain
Silvia De Santis
10:20 - 10:40High-density neurometabolic mapping and network analysis in alcohol dependent rats
Cornelius C. W. Willacey
10:40 - 11:00Advanced Network analysis of cFos responses reveals distinct brain states for alcohol and sweet memory recall
Maria Ercsey-Ravasz
11:00 - 11:10Discussions
11:10 - 11:30Coffee break
11:30 - 13:00Session 11
YIS 2 Addiction studies/Nordmann Award
Chairs: Raul Muresan, Philippe de Timary
11:30 - 11:50Searching for treatment-sensitive neural biomarkers of addiction: is there light at the end of the MRI-tunnel?
Patrick Bach (Nordmann Award Winner)
11:50 - 12:00Engagement of brain stress-reward systems in alcohol-dependent mice and rats
Elizabeth M Avegno
12:00 - 12:10LRRK2, a parkinson's-associated protein, regulates striatal D1 receptor function and compulsive-like alcohol drinking in mice
Daniel da Silva
12:10 - 12:20Memory and synaptic plasticity impairment after the very first binge drinking episodes in adolescent rats: Is there a link between inflammation and glutamate?
Chloé Deschamps
12:20 - 12:30Discovery and characterization of ADE and non-ADE rats under long-term alcohol exposure protocol. Biochemical differences in rat brain during alcohol abstinence.
Sandra Fernández-Rodríguez
12:30 - 12:40Identification and validation of expert patient intervention areas in addictology with patients hospitalized for addiction disorders
Chanaëlle Obadia
12:40 - 12:50A Dominance Analysis Approach Applied to Psychological Factors Associated with Binge Drinking among University Students
Maxime Mauduy
12:50 - 13:00Discussions
13:00 - 14:00Lunch and Poster Session
14:30 - 14:40Break
14:40 - 16:10Session 14
Diagnosis and Interventions in FASD: From Genes to eHealth
Chairs: Rainer Spanagel, Mike Suttie
14:40 - 15:00Introductory comments on FASD and the Collaborative Initiative on FASD
Edward Riley
15:00 - 15:20Exposure to ethanol leads to midfacial hypoplasia in VANGL2 mutants via indirect interactions with the SHH pathway
Johann Eberhart
15:20 - 15:40The role of sex and genetic variation in a mouse model of FAS
Scott Parnell
15:40 - 16:00Utilizing 3D facial Analysis to Estimate the Prevalence of Minor Facial Anomalies in FASD
Mike Suttie
16:00 - 16:10Development and Evaluation of Digital and Mobile Health Interventions (eHealth) for FASD
Christie Petrenko
16:10-16:30Coffee break
16:30 - 18:00Session 17
Translational Neuroimaging in Alcoholism II: Mapping global network interactions
Chairs: Wolfgang H. Sommer, Raul Muresan
16:30 - 16:50Structural mapping and higher brain function
Phillippe de Timary
16:50 - 17:10Altered diffusivity in the alcoholic brain - what are the functional consequences
Santiago Canals
17:10 - 17:30Probing functional brain networks in alcoholism by using advanced signal processing techniques and machine learning
Raul Muresan
17:30 - 17:50 Using machine learning, structural differences in adolescent brains can predict alcohol misuse in the future
Roshan Rane
17:50 - 18:00 Discussions
09:00 - 09:30Keynote Lecture:
Chair: Ioan Sporea
Alcoholic cirrhosis and reversibility
Massimo Pinzani
09:30 - 09:40Break
09:40 - 11:10Session 21 - Postgraduate Course
Epidemiology, cancer and neurology in drinkers
Chairs: Vasilis Vasiliou, Jürgen Rehm, Manuela Neuman
09:40 - 10:00Epidemiology of alcohol and opioids
Jürgen Rehm
10:00 - 10:20Mechanisms of alcohol-induced cancer
Vasilis Vasiliou
10:20 - 10:40Alcohol-induced rare malignancy
Manuela G. Neuman
10:40 - 11:00Wernicke-Korsakoff syndrome
Alain Dervaux
11:00 - 11:10Discussions
11:10 - 11:40Coffee break
11:40 - 12:10Keynote Lecture:
Chair: Marcin Wojnar
Losing and regaining control over alcohol intake
Rainer Spanagel
12:20 - 13:20Session 24 - Postgraduate Course
Legal aspects and management of acute disease
Chairs: Roxana Sirli, Camelia Cojocaru
12:20 - 12:35Legal aspects of alcoholic intake
Alexandra Enache
12:35 - 12:50How to manage agressive withdrawal
Virgil Enatescu
12:50 - 13:05Microbiota and alcoholic liver
Alina Popescu
13:05 - 13:20AddictHelp: the Cluj experience in interdisciplinary approach of AUD
Horia Stefanescu
13:20 - 13:40Lunch presentation: Understanding microbiota - autoimmunity, probiotic bacteria and infection
Roxana Sirli
13:20 - 14:20Lunch
14:20 - 15:50Session 27 - Postgraduate Course
Alcoholism and the heart liver axis
Chairs: Ioan Sporea, Adina Ionac
14:20 - 14:38Ethanol and heart failure
Adina Ionac
14:38 - 14:56French Paradox – truth or challenge
Gaita Dan
14:56 - 15:14Elastography for screening in ALD
Ioan Sporea
15:14 - 15:32Alcoholic cardiomyopathy: Pathogenic aspects
Joaquim FernÁndez Sola
15:32 - 15:50Revisiting the role of HVPG and transjugular liver biopsy in alcoholic hepatitis
Bogdan Procopet
15:50-16:00Closing Remarks
16:30-18:00ESBRA Board meeting 2, New Board
09:40 - 11:10Session 19
Alcohol and metabolic syndrome
Chairs: Alexandre Louvet, Christophe Moreno
09:40 - 10:00Alcohol and metabolic syndrome: clinical aspects
Philippe Mathurin
10:00 - 10:20Alcohol, metabolic syndrome and the liver: epidemiology
Helena Cortez-Pinto
10:20 - 10:40Histological lesions can predict response to corticosteroids in patients with severe alcohol-reated steatohepatitis (ASH)
Karoline Lackner
10:40 - 11:00Screening for NAFLD and ALD in patients with type 2 diabetes and in general population
Hannes Hagström
11:00 - 11:10Discussions
11:10 - 11:40Coffee break
12:20 - 13:20Session 22
YIS 4 Liver disease
Chairs: Shilpa Chokshi, Karoline Lackner
12:20 - 12:30Spleen stiffness to liver stiffness ratio in ALD
Omar Elshaarawy
12:30 - 12:40Alcohol use disorder and alcohol related liver disease: time for screening?
Camelia Foncea
12:40 - 12:50Elevated S-adenosylhomocysteine-induced dipose dysfunction promotes alcohol-associated liver steatosis
Madan Kumar Arumugam
12:50 - 13:00Distinct Mechanisms of Liver Cancers Between Alcoholic and Nonalcohlic Fatty Liver Diseases in Diabetic Murine Models
Liya Pi
13:00 - 13:10Role of Gut Hormones, Ghrelin and Liver-Expressed Antimicrobial Peptide-2 Dysregulation in Alcohol-Associated Liver Disease Pathogenesis
Karuna Rasineni
13:10 - 13:20Discussions
13:40 - 14:20Workshop
13:20 - 14:20Lunch
14:20 - 15:50Session 25
Modifiers of alcoholic liver disease
Chairs: Steven Dooley, Ina Bergheim
14:20 - 14:40Intestinal bacteria and bacterial endotoxin in the development and therapy of alcohol-related liver disease
Ina Bergheim
14:40 - 15:00Alcohol-related liver disease, hemolysis and iron signaling
Shijin Wang
15:00 - 15:20Role of environmental toxins and nanoplastics in the pathogenesis of (N)AFLD
Felix Englert
15:20 - 15:40Influence of hepatic preinjury on development of alcohol-related and other chronic liver disease
Steven Dooley
15:40 - 15:50Discussions
09:40 - 11:10Session 20
YIS3 addiction studies
Chair: Mickael Naassila, Oliver Pierrefiche
09:40 - 09:50More than just an alcoholic person: Preventing stigma and dehumanization with multiple categorization
Pauline Rasset
09:50 - 10:00Epigenetic mechanisms underlying alcohol use and anxiety disorders
Estelle Barbier
10:00 - 10:10 Early recovery of neuropsychological impairments during detoxification in patients with alcohol use disorder
Bernard Angerville
10:10 - 10:20Adverse childhood experiences (ACES) in young children with fetal alcohol spectrum disorder (FASD) and effect on behavior problems
Carson Kautz-Turnbull
10:20 - 10:30Pilot study CANNAVAP: efficiency of cannbidiol inhaled with a vaping device in cannabis reduction or withdrawal
Gregoire Cleirec
10:30 - 10:40Benefits of abstinence of chronic alcohol exposure-induced aggressiveness in cellular models of hepatocellular carcinoma
Constance Marié
10:40 - 10:50Deep transcranial magnetic stimulation as a treatment for alcohol use disorderIrene Perini
10:50 - 11:00Discussions
11:10 - 11:40Coffee break
12:20 - 13:20Session 23
From 3-R to 6-R: Improved ethics for the use of animals towards narrowing the translational gap in alcohol use disorder
Chair: Marcus Meinhardt, Björn Gerlach
12:20 - 12:35Refining animal models in the field of alcohol use disorder
Marcus Meinhardt
12:35 - 12:50The PREPARE guidelines: An overarching guidance on how to plan animal experiments
Adrian Smith
12:50 - 13:05EQIPD - A systematic approach to enhance research data quality
Björn Gerlach
13:05 - 13:20Reporting guidelines for non-clinical data
Kaitlyn Hair
13:20 - 14:20Lunch
14:20 - 15:50Session 26
Alcohol and Older Adults: Insights from Behavioral and Brain Studies 
Chair: Mickael Naassila, Wolfgang Sommer
14:20 - 14:40Epidemiology of Harmful Drinking Among Older Adults: Life Course Origins and Public Health Implications
Katherine M. Keyes
14:40 - 15:00Age-related Vulnerability at Socially-Relevant Doses
Sara Jo Nixon
15:00 - 15:20Neuroinflammation al the intersection between alcohol and aging
Terence Deak
15:20 - 15:40Increased sensitivity to ethanol in aged animals: potential neurobiological mechanisms
Douglas B Matthews
15:40 - 15:50Discussions
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