Scientific program 2021-09-15T19:15:38+00:00

Scientific program / preliminary program

09:00 - 10:00Registration
10:00 - 10:30Opening Ceremony
Sebastian Mueller, Ioan Sporea
10:30 - 11:00Keynote Lecture:
Chair: Sebastian Mueller
Alcoholic hepatitis – from diagnosis to treatment
Phillipe Mathurin
11:00 - 11:30Keynote Lecture:
Chair: TBA
Alcohol and microbiome in ALD
Gyongyi Szabo
11:30 - 12.00Coffee break
12.00 - 13:30Session 3 - Postgraduate Course
Measuring alcohol consumption
Chairmen: TBA, Rainer Spanagel
Tools to detect unhealthy alcohol consumption
Friedrich M. Wurst
Measuring alcohol consumption
Roberta Agabio
Diagnosis of alcohol use disorder and identification of unhealthy alcohol consumption
Anne Lingford-Hughes
Animals models used to study alcohol use disorder
Rainer Spanagel
13:30 - 14:30Lunch
14:30 - 16:00Session 6 - Postgraduate Course
EASL ESBRA joint symposium: Epidemiology of ALD: What are the real numbers?
Chairmen: Manolis Tsochatzis, Sebastian Mueller
Policies to reduce the burden of ALD
Nick Sheran
Epidemiology of alcohol-related liver disease in Europe
Peter Jepsen
Noninvasive biomarker screening and ALD in the general population
Maja Thiele
Non-invasive fibrosis assessment
Manolis Tsochatzis
16:00 - 16:30Break
17:30 - 19:00Opening Ceremony - Romanian National Opera
19:00 - 21:00 Welcome drinks at the conference Center (Recas Winery - Speakers)
12.00 - 13:30Session 1
Mechanisms and Therapeutics of Acute-on-chronic Liver Failure (ACLF) and YIS1 Liver
Chairmen: Rajiv Jalan, Christophe Moreno
Gasdermin-D in endotoxin lethality and AH
Gautam Mehta
Hepatocyte transcriptional reprogramming in AH
Josepmaria Argemi
Transcriptional changes in the pathological divergence of acute alcoholic hepatitis and cirrhosis
Brandon J. Peiffer
YAP and liver regeneration in severe AH
Line Carolle Ntandja Wandji
Treatment of ACLF using synergistic action of G-CSF and TLR4 inhibitor TAK-242 (G-TAK)
Cornelius Engelmann
13:30 - 14:30Lunch
14:30 - 16:00Session 4
COVID and Alcohol Use Disorder
Chairmen: TBA
Impact of COVID-19 confinement on alcohol purchases in Great Britain: controlled interrupted time-series analysis during the first half of 2020 compared with 2015-2018
Peter Anderson
The effect of Covid-19 on alcohol use disorder and role of universal alcohol screening in an inpatient setting: a retrospective cohort control study
Mohsan Subhani
Lockdown drinking: how alcohol consumption trends have responded to the pandemic
Katherine Severi
Treatment and prevention strategies during lockdown
Peter Rice
12.00-13:30Session 2
New mechanisms involved in alcohol use disorder and new therapeutics : insights from the preclinical side 
Chairmen: Mickael Naassila, Sebastien Carnicella
Role of GPR88 in alcohol addiction and as a new therapeutic target
Sami Ben Hamida
Transcranial direct current stimulations (tDCS) reduce motivation to drink ethanol and reacquisition of ethanol self-administration in mice
Vincent Van Waes
Behavioral and brain Effects of psilocybin in a relevant animal model of binge drinking
Jérôme Jeanblanc
Role of nigrostriatal pathway in motivated behaviors and alcohol use disorder
Raphaël Goutaudier
13:30 - 14:30Lunch
14:30 - 16:00Session 5
New insights into neuroinflammatory processes induced by ethanol exposure during early or late brain developmental periods
Chairmen: Oliver Pierrefiche, Maria Pascual
Cannabinoids modulate cognitive deficits and neuroinflammation induced by early alcohol exposure
Olga Valverde
Gasdermin-D in endotoxin lethality and AH
Hide Tsukamoto
Role of exosomes as biomarkers of the neuroinflammation induced by adolescent binge drinking
María Pascual
Binge drinking, inflammation and GluN2B subunits: a ménage à trois to explain cognitive deficits and hippocampus plasticity dysfunctions during adolescence in rats
Oliver Pierrefiche
PET imaging for preclinical investigation of ethanol-induced neuroinflammation in adolescent animals
Wadad Saba
Round Table Discussion
09:00 - 09:30Keynote Lecture:
Chair: Giovanni Addolorato
Transcranial Magnetic Stimulation in addiction therapies
Marco Diana
09:30 - 09:40Coffee break
09:40 - 11:10Session 9 - Postgraduate Course
Acute-on-chronic Liver Failure (ACLF) in Alcoholic Hepatitis Patients
Chairmen: TBA, Sebastian Mueller
Overview of ACLF
Rajiv Jalan
ACLF in Alcoholic Hepatitis
Christophe Moreno
Translational omic analysis of ACLF in Alcoholic Hepatitis
Ramon Bataller
Liver transplantation rescues Alcoholic Hepatitis patients with ACLF
Alexandre Louvet
11:10 - 11:30Coffee break
11:30 - 13:00Session 12 - Postgraduate Course
Alcohol effects on brain and treatments
Chairmen: Giovanni Addolorato, Mickael Naassila
Brain alterations and cognitive deficits induced by alcohol use disorder
Mickael Naassila
Medical treatment of alcohol use disorder: A multidisciplinary approach
Julia Sinclair
Comorbidity with substance use disorders and/or psychiatric disorders
Marcin Wojnar
Emergency Room: Acute alcohol intoxication and other alcohol-related acute problems (except AWS)
Giovanni Addolorato
13:00 - 14:00Lunch and Poster Session
14:00 - 14:30Keynote Lecture:
Chair: Shilpa Chokshi
Novel medications and addiction
Lorenzo Leggio
14:30 - 14:40Coffee break
14:40 - 16:10Session 15 - Postgraduate Course
Alcohol withdrawal and primary care
Chairmen: Marcin Wojnar, TBA
Alcohol withdrawal syndrome
Nicola Kalk
Treatments for Adolescent Alcohol Use
Lindsay Squeglia
Potential New Medications for the treatment of alcohol use disorder and experimental medications
Lorenzo Leggio
Confounders of liver stiffness and algorithms in alcoholics
Sebastian Mueller
16:10 - 16:30Coffee break
16:30 - 18:00Session 18 - Postgraduate Course
Intensive care- Acute alcoholism management
Chairmen: Liana Gheorghe, Ioan Sporea
Acute liver failure due to alcohol intoxication- therapeutic options
Carmen Fierbinteanu
Severe acute ethanolic intoxication- management of critical ill patient
Ovidiu Bedreag
Coagulation disorders in patients with alcoholic liver cirrhosis
Liana Gheorghe
Hepato- renal syndrome in patients with acute alcoholic intoxication
Anca Trifan
Particularities of intensive care in patients with alcohol use disorder
Dorel Sandesc
18:00 - 19:00General assembly
20:00Get together party - Curtea berarilor - Oktoberfest
20:00Awards, Toasts
09:40 - 11:10Session 7
11:10 - 11:30Coffee break
11:30 - 13:00Session 10
The role of inter-organ communication in alcohol induced tissue injury
Chairmen: TBA
Alcohol-induced tissue injury in skeletal muscle and adipose tissue; targets or relays for interorgan axis
Patricia E. Molina
Impact of alcohol and aldehyde on innate lung defense: Liver-lung axis.
Todd A. Wyatt
Alcohol-induced gut microbial dysbiosis plays a major role in driving the pathogenic changes in the gut-liver-brain-axis.
Shirish Barve
Kusum K. Kharbanda
Natalia A. Osna
13:00 - 14:00Lunch and Poster Session
14:30 - 14:40Coffee break
14:40-16:10Session 13
Alcohol-Related liver disease (ALD) – a global epidemic
Chairmen: Shilpa Chokshi, Elena Palma
Pathogenesis and diagnosis of ALD
Matthew Cramp
Genetic profiling as a tool to advance therapeutic discovery in ArLD
Marsha Morgan
Mitochondrial therapy for ArLD - fact or fiction?
Jose C Fernandez-Checa
Big data in ALD: how are multi-omic studies advancing the development of therapeutics for ALD
Ramon Bataller
16:10 - 16:30Coffee break
16:30 - 18:00Session 16
ALD, NAFLD and bowel disease
Chairmen: TBA
Inflammatory bowel disease and alcohol-induced injury
Ioana Duca Grigorescu
Non-alcoholic steatohepatitis and the microbiome
Steve Malnick
Dysfunction of Intestinal Antimicrobial Peptides in the Pathogenesis of Alcoholic Hepatitis
Wei Zhong
H2O2-mediated autophagy during ethanol metabolism
Cheng Chen
Apoptosome and Inflammasome: Non-invasive biomarkers in heavy drinkers undergoing alcohol detoxification
Manuela G. Neuman
Chaperone-Mediated Autophagy Substrate Stabilization Potentiates EtOH-Induced Lipogenesis in Liver Cells
Paul Thomes
9:40 - 11:10Session 8
Translational Neuroimaging in Alcoholism I: Novel approaches to neuro-immune and functional networks
Chairmen: Wolfgang H. Sommer, Maria Ercsey-Ravasz
Alcohol, Microbiota and Brain function
Sophie Leclercq
Advanced DTI to identify glia responses in the alcoholic brain
Silvia De Santis
Advanced Network analysis of cFos responses reveals distinct brain states for alcohol and sweet memory recall
Maria Ercsey-Ravasz
High-density neurometabolic mapping and network analysis in alcohol dependent rats
Cornelius C. W. Willacey
11:10 - 11:30Coffee break
11:30 - 13:00Session 11
YIS 2 Addiction studies/Nordmann Award
Chairmen: TBA
Searching for treatment-sensitive neural biomarkers of addiction: is there light at the end of the MRI-tunnel?
Patrick Bach (Nordmann Award Winner)
LRRK2, a parkinson's-associated protein, regulates striatal D1 receptor function and compulsive-like alcohol drinking in mice
Daniel da Silva
Memory and synaptc plasticity impairment after teh very first binge drinking episodes in adolescent rats: Is there a link between inflammation and glutamate?
Chloé Deschamps
Discovery and characterization of ADE and non-ADE rats under long-term alcohol exposure protocol. Biochemical differences in rat brain during alcohol abstinence.
Sandra Fernández-Rodríguez
Identification and validation of expert patient intervention areas in addictology with patients hospitalized for addiction disorders
Chanaëlle Obadia
A Dominance Analysis Approach Applied to Psychological Factors Associated with Binge Drinking among University Students
Maxime Mauduy
Engagement of brain stress-reward systems in alcohol-dependent mice and rats
Elizabeth M Avegno
13:00 - 14:00Lunch and Poster Session
14:30 - 14:40Coffee break
14:40 - 16:10Session 14
Diagnosis and Interventions in FASD: From Genes to eHealth
Chairmen: Edward Riley, Mike Suttie
Introductory comments on FASD and the Collaborative Initiative on FASD
Edward Riley
Exposure to ethanol leads to midfacial hypoplasia in VANGL2 mutants via indirect interactions with the SHH pathway
Johann Eberhart
The role of sex and genetic variation in a mouse model of FAS
Scott Parnell
Utilizing 3D facial Analysis to Estimate the Prevalence of Minor Facial Anomalies in FASD
Mike Suttie
Development and Evaluation of Digital and Mobile Health Interventions (eHealth) for FASD
Christie Petrenko
16:10-16:30Coffee break
16:30 - 18:00Session 17
Translational Neuroimaging in Alcoholism II: Mapping global network interactions
Chairmen: Wolfgang H. Sommer, Raul Muresan
Structural mapping and higher brain function
Phillippe de Timary
Altered diffusivity in the alcoholic brain - what are the functional consequences
Santiago Canals
Probing functional brain networks in alcoholism by using advanced signal processing techniques and machine learning
Raul Muresan
Using machine learning, structural differences in adolescent brains can predict alcohol misuse in the future
Roshan Rane
09:00 - 09:30Keynote Lecture:
Chair: Ioan Sporea
Alcoholic cirrhosis and reversibility
Massimo Pinzani
09:30 - 09:40Coffee break
09:40 - 11:10Session 21 - Postgraduate Course
Epidemiology, cancer and neurology in drinkers
Chairmen: TBA, Jürgen Rehm
Epidemiology of alcohol and opioids
Jürgen Rehm
Mechanisms of alcohol-induced cancer
Vasilis Vasiliou
Alcohol-induced rare malignancy
Manuela G. Neuman
Wernicke-Korsakoff syndrome
Alain Dervaux
11:10 - 11:40Coffee break
11:40 - 12:10Keynote Lecture:
Chair: Marcin Wojnar
Losing and regaining control over alcohol intake
Rainer Spanagel
12:20 - 13:20Session 24 - Postgraduate Course
Legal aspects and management of acute disease
Chairmen: Roxana Sirli, Anca Trifan
Legal aspects of alcoholic intake
Alexandra Enache
How to manage agressive withdrawal
Virgil Enatescu
Microbiota and alcoholic liver
Alina Popescu
AddictHelp: the Cluj experience in interdisciplinary approach of AUD
Horia Stefanescu
13:20 - 14:20Lunch
14:20 - 15:50Session 27 - Postgraduate Course
Alcoholism and the heart liver axis
Chairmen: Carmen Fierbinteanu, Cristina Cijevschi- Prelipcean
Ethanol and heart failure
Adina Ionac
French Paradox – truth or challenge
Gaita Dan
Elastography for screening in ALD
Ioan Sporea
FernÁndez Sola
Revisiting the role of HVPG and transjugular liver biopsy in alcoholic hepatitis
Bogdan Procopet
15:50-16:00Closing Remarks
16:30-18:00ESBRA Board meeting 2
09:40 - 11:10Session 19
Alcohol and metabolic syndrome
Chairmen: Alexandre Louvet, Christophe Moreno
Alcohol and metabolic syndrome: clinical aspects
Philippe Mathurin
Alcohol, metabolic syndrome and the liver: epidemiology
Helena Cortez-Pinto
Screening for NAFLD and ALD in patients with type 2 diabetes and in general population
Hannes Hagström
11:10 - 11:40Coffee break
12:20 - 13:20Session 22
YIS 4 Liver disease
Chairmen: Shilpa Chokshi, Karoline Lackner
Spleen stiffness to liver stiffness ratio in ALD
Omar Elshaarawy
Alcohol use disorder and alcohol related liver disease: time for screening?
Camelia Foncea
Elevated S-adenosylhomocysteine-induced dipose dysfunction promotes alcohol-associated liver steatosis
Madan Kumar Arumugam
Role of Gut Hormones, Ghrelin and Liver-Expressed Antimicrobial Peptide-2 Dysregulation in Alcohol-Associated Liver Disease Pathogenesis
Karuna Rasineni
Distinct Mechanisms of Liver Cancers Detween Alcoholic and Nonalcohlic Fatty Liver Diseases in Diabetic Murine Models
Liya Pi
13:20 - 14:20Lunch
14:20 - 15:50Session 25
Modifiers of alcoholic liver disease
Chairmen: TBA, Ina Bergheim
Intestinal bacteria and bacterial endotoxin in the development and therapy of alcohol-related liver disease
Ina Bergheim
Alcohol-related liver disease, hemolysis and iron signaling
Shijin Wang
Influence of hepatic preinjury on development of alcohol-related and other chronic liver disease
Steven Dooley
09:40 - 11:10Session 20
YIS3 addiction studies
Chairmen: Mickael Naassila, Oliver Pierrefiche
More than just an alcoholic person: Preventing stigma and dehumanization with multiple categorization
Pauline Rasset
Epigenetic mechanisms underlying alcohol use and anxiety disorders
Estelle Barbier
Early recovery of neuropsychological impairments during detoxification in patients with alcohol use disorder
Bernard Angerville
Adverse childhood experiences (ACES) in young children with fetal alcohol spectrum disorder (FASD) and effect on behavior problems
Carson Kautz-Turnbull
Pilot study CANNAVAP: efficiency of cannbidiol inhaled with a vaping device in cannabis reduction or withdrawal
Gregoire Cleirec
Benefits of abstinence of chronic alcohol exposure-induced aggressiveness in cellular models of hepatocellular carcinoma
Constance Marié
11:10 - 11:40Coffee break
12:20 - 13:20Session 23
From 3-R to 6-R: Improved ethics for the use of animals towards narrowing the translational gap in alcohol use disorder
Chairmen: Marcus Meinhardt, Björn Gerlach
Refining animal models in the field of alcohol use disorder
Marcus Meinhardt
The PREPARE guidelines: An overarching guidance on how to plan animal experiments
Adrian Smith
EQIPD - A systematic approach to enhance research data quality
Björn Gerlach
Reporting guidelines for non-clinical data
Thomas Steckler
13:20 - 14:20Lunch
14:20 - 15:50Session 26
Alcohol and Older Adults: Insights from Behavioral and Brain Studies 
Chairmen: TBA
Epidemiology of Harmful Drinking Among Older Adults: Life Course Origins and Public Health Implications
Katherine M. Keyes
Age-related Vulnerability at Socially-Relevant Doses
Sara Jo Nixon
Neuroinflammation al the intersection between alcohol and aging
Terence Deak
Increased sensitivity to ethanol in aged animals: potential neurobiological mechanisms
Douglas B Matthews
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